Best Supplements for Mitochondria

Best Supplements for Mitochondria

Supplements that support mitochondrial function mitochondrial support supplements to help with chronic fatigue and oxidative damage Mitochondria is the powerhouse of every cell; its function is to generate the energy needed so that the body functions as normal. With age, mitochondria function naturally declines, which decreases cognitive function, and causes fatigue symptoms, and an array of other health issues. Other factors such as stress and a poor diet also can lead to mitochondrial dysfunction. For this reason, supplements are essential to support mitochondrial function and health. Mitochondria are responsible for cellular energy production needed for our bodies to function. Incorporating supplements into a daily routine can enhance mitochondrial function and promote better vitality and health. Mitochondrial supplements are important in order to improve energy production, reduce oxidative stress, and improve mitochondrial function.

Why Supplements are Helpful for Mitochondria

proper mitochondrial supplementation can help fight many mitochondrial dysfunction disorders and cardiovascular disease Mitochondria supplements or vitamins can support and enhance mitochondrial function helping to upkeep mitochondrial DNA. They do this by helping, on a cellular level, to help mitochondria function properly. Mitochondria produce energy by transforming food into energy. For this reason, specific micronutrients and vitamins can influence mitochondrial function, playing a critical role in energy metabolism and production. Mitochondrial dysfunction inevitably leads to chronic fatigue syndrome, oxidative stress, and certain mitochondrial diseases. Hence, ensuring mitochondrial health is essential. It is essential nutrients, amino acids, and vitamins are kept at adequate levels, this ensures that mitochondria are healthy and energy production is also adequate. Diet alone often doesn’t provide all the nutrients that we need, this is where dietary supplements come in.

Best Supplements for Mitochondria

Supplements that support mitochondrial function can create energy production, help treat chronic fatigue syndrome, and help cellular energy production, amongst other benefits. Importantly, mitochondrial dysfunction and oxidative stress can lead to cardiovascular disease as well as other health issues. Below are the best supplements, amino acids, and nutrients to support overall mitochondrial function.

Omega-3 Fatty Acids

Omega-3 fatty acids can help prevent mitochondrial illnesses and improve mitochondrial health Omega-3 Fatty Acids are an essential vitamin that helps support health on many different levels. Research has found that omega-3 supplementation can have positive mitochondrial effects, such as promoting adenosine triphosphate sensitivity and also impacting the composition of mitochondrial membranes. Adenosine triphosphate is an energy-carrying molecule which helps the cell to produce energy and mitochondrial metabolism. Other research has also suggested that supplementing omega-3 can also help to reverse mitochondrial dysfunction as a result of certain health conditions related to the liver and heart. Omega-3 supplementation should be considered especially for age-related mitochondrial failure. A diet rich in salmon, flaxseed, and tuna will provide you with omega-3 fatty acids but supplementation is recommended to ensure that levels remain healthy.


Resveratrol, a polyphenol, has been shown to improve mitochondrial function and biogenesis – the growth and division of mitochondria. This can help with energy production and help to reduce oxidative stress and fatigue symptoms. Resveratrol has been shown to slow down the ageing process in a body, something that mitochondrial function is heavily involved in. A study found that resveratrol positively influences mitochondrial generic and enzymatic mechanisms. Certain foods such as peanuts, grapes, and pistachios are rich in resveratrol. However, supplementing this polyphenol ensures that levels are kept adequate. Resveratrol is known as being one of the best healthy mitochondrial-boosting polyphenols.

Coenzyme Q10

Coenzyme Q10 (CoQ10) is concentrated in the mitochondria. For this reason, this nutrient is essential to cellular energy production. It does this by improving glycemic control and modulates mitochondrial function but supporting electron transport. Furthermore, CoQ10 deficiency has also been found to be an indicator of mitochondrial dysfunction. CoQ10 combined with a healthy diet and exercise can actually counteract mitochondrial dysfunction. This supplement is essential for overall mitochondrial health and mitochondrial dysfunction. CoQ10 is a potent antioxidant and supplementing it will help support healthy mitochondrial function. Mitochondrial dysfunction inevitably leads to muscle weakness, vision loss, and cognitive issues. There is evidence linking oxidative damage to various mutations, and mitochondria DNA is highly susceptible to oxidative stress markers.

Nicotinamide Riboside

Nicotinamide Riboside is a form of vitamin B3 and is a predecessor to nicotinamide adenine dinucleotide, a coenzyme that is absolutely essential for mitochondrial function and helps mitochondria produce energy. Nicotinamide Riboside can help to increase nicotinamide adenine dinucleotide levels, which supports energy production, sirtuin activation, and DNA repair. This supplement has been found to reduce oxidative stress markers, as well as aid in alleviating fatigue symptoms. For these reasons, Nicotinamide Riboside is a promising supplement to help alleviate the potential of mitochondrial dysfunction and help to produce cellular energy.

Pyrroloquinoline Quinone

Pyrroloquinoline Quinone (PQQ) is a potent antioxidant that helps in the biogenesis of mitochondrial function. This is the process in which new mitochondria are created within the cells and aids in energy production and mitochondrial health. PQQ has also been proven to protect against oxidative stress and enhance mitochondrial function. Supplementing PQQ can help to maintain youthful mitochondrial function and energy production. Certain foods also contain PQQ such as legumes, kiwi, parsley, and green peppers.


Magnesium is an essential mineral that plays a vital role in the activation of enzymes. It is a crucial mineral for many bodily functions. Magnesium has also been found to support mitochondrial function. When magnesium levels are below average mitochondrial function can be negatively affected. Supplementing magnesium ensures that your mitochondria have the necessary cofactors for optimal energy production. Legumes, leafy greens, and nuts all contain magnesium. Supplementing magnesium is recommended, as most people don’t get the necessary levels from their diet alone.

Alpha-Lipoic Acid (ALA)

Alpha lipoic acid (ALA) is another powerful antioxidant, it protects the mitochondria from oxidative stress and damage. This is essential to ensure that these powerhouses are kept healthy and alpha lipoic acid can help with this. Alpha lipoic acid also helps the mitochondria by helping to regenerate other antioxidants such as vitamins E and C. Alpha lipoic acid helps with overall mitochondrial health, and energy production, and prevents primary mitochondrial disorders and primary mitochondrial disorders and mitochondrial dysfunction. Alpha lipoic acid promotes overall cellular health and enhances energy production. This helps elevate feelings of fatigue and aiding in overall health. For this reason, ALA has also been associated with reversing the ageing process.

Rhodiola Rosea

Rhodiola Rosea is a herb that has been used in herbal medicine for centuries, commonly associated with mental health benefits such as being a natural stress buster. However, it has also been found to improve mitochondrial function by increasing the number of mitochondria in cells and also enhancing the utilisation of oxygen. Rhodiola Rosea can also help to reduce the impact of stress on mitochondrial health. Rhodiola Rosea can be found in supplementation form and has been found to help aid in reduced fatigue and also reducing oxidative stress. This supplement can help prevent mitochondrial dysfunction and increase cellular energy.


L-carnitine is one of the amino acids that play a vital role in the transportation of fatty acids to the mitochondria. It then uses this fatty acid metabolism as a way to produce energy. Foods that contain L-carnitine are normally in animal products such as beef steak, pork, and dairy products. For this reason, supplementing L-carnitine is particularly advised for those with vegetarian or vegan diets. Supplementing L-carnitine improves the overall efficiency of energy metabolism and supports overall mitochondrial function and health. Improved mitochondrial function can lead to important cellular longevity function and improved cellular energy production.


Curcumin is the active compound found in turmeric and is known in the traditional medicine world for its antioxidant and anti-inflammatory properties. Curcumin has the potential to protect mitochondria from oxidative stress and also improve mitochondrial function. Furthermore, curcumin can support the production of BDNF, something that is essential for neuron function and health as well as producing cellular energy and improving mitochondrial function and mitochondrial health. Curcumin supplements have extremely promising health benefits. One of these benefits includes maintaining mitochondrial function and integrity.

What Are the Benefits of Using Natural Supplements for Mitochondria?

Natural mitochondria supplements enhance cellular power, providing various benefits. These supplements can boost energy levels, support brain function, and improve overall cellular health. They can also help in combating oxidative stress and supporting the body’s natural defense mechanisms. Additionally, they can aid in enhancing physical performance and promoting longevity.

The Takeaway

Mitochondria are incredibly important to cell function, supporting and optimising mitochondrial function as well as preventing mitochondrial dysfunction. It is this that is so important for maintaining overall health and vitality, especially as we age. The supplements mentioned above can all play a significant role in enhancing mitochondrial health. Remember, before starting any new supplement regime, it is crucial to consult with a healthcare professional to ensure that they are safe and appropriate for your health needs. This is especially true for those with existing health conditions or issues. Supplements should only be used in conjunction with a healthy diet, regular exercise, and a balanced lifestyle – all of which can also contribute to healthy mitochondria.


What are mitochondria, and why are they important for our health?

Mitochondria are tiny organelles within our cells that are often referred to as the “powerhouses” of our cells. They are responsible for producing energy through a process known as cellular respiration. Maintaining healthy mitochondria is crucial because they play a significant role in overall health and vitality. As we age, mitochondrial function can decline, leading to various health issues. Supplements can help support and optimise mitochondrial function, potentially leading to reduced fatigue, cognitive function, reduced oxidative stress, and overall well-being.

Are these supplements safe to take?

Generally, these supplements are safe when taken at recommended doses. However, it’s essential to consult with a healthcare professional before starting any new supplement regimen, especially if you have underlying health conditions, are pregnant or breastfeeding, or are taking other medications. The cardiovascular system strongly depends on mitochondrial health but checking with a healthcare provider beforehand is essential.

Can I get these nutrients from my diet instead of taking supplements?

Yes, many of these nutrients and amino acids are found in various foods. However, in some cases, it may be challenging to obtain therapeutic doses solely from your diet which might not lead to the same level of cellular energy. Adequate mitochondrial energy production can be properly achieved with the extra help from vitamins and nutrients. Supplements can provide a more concentrated and convenient source of these nutrients to support mitochondrial health, which can help fight chronic fatigue syndrome and oxidative stress.

How long should I take these supplements to see noticeable benefits for my mitochondrial health?

The time it takes to see noticeable benefits may vary from person to person. Some individuals may experience improvements within a few weeks, while others may require several months of consistent supplementation. There’s no set time scale for when these supplements can help with proper mitochondrial functioning. It’s essential to be patient and monitor your health while taking these supplements. Proper mitochondrial supplementation has been proven to help with mitochondrial health and prevent mitochondrial dysfunction disorders.

Are there any potential side effects or interactions to be aware of with these supplements?

While these supplements are generally safe, it’s essential to consult with a healthcare professional before starting any new regimen, as there may be potential interactions with medications or individual sensitivities. Additionally, some individuals may experience mild side effects, such as digestive discomfort, when taking certain supplements. Many of these supplements have been taken studied in controlled clinical trials and documented positive mitochondrial effects.      


Get the latest health advice from top experts in your inbox, every week.