L-Tyrosine is a naturally occurring amino acid that plays a crucial role in the production of various important neurotransmitters in the human body. It is synthesized from another amino acid called phenylalanine and is found in many protein-rich foods such as meat, dairy products, and legumes. As a non-essential amino acid, L-Tyrosine can be produced by the body, but its availability may be limited under certain conditions, such as stress, intense physical activity, or illness. In such cases, dietary sources or supplementation may be necessary to maintain optimal levels. Once ingested, L-Tyrosine is converted into several key neurotransmitters, including dopamine, norepinephrine, and epinephrine. These neurotransmitters are involved in various physiological processes, such as mood regulation, stress response, cognitive function, and overall mental well-being. Furthermore, L-Tyrosine is also a precursor to the synthesis of thyroid hormones, which are vital for maintaining a healthy metabolism and regulating energy levels. It is worth noting that L-Tyrosine’s conversion into neurotransmitters and thyroid hormones is a complex process that requires the presence of specific enzymes and co-factors. Due to its role in neurotransmitter synthesis, L-Tyrosine has garnered attention for its potential cognitive and mood-enhancing effects. Additionally, it has been studied for its potential benefits in supporting stress adaptation, cognitive performance under demanding conditions, and overall mental resilience. However, it is important to note that individual responses to L-Tyrosine supplementation may vary, and caution should be exercised when considering its use. As with any dietary supplement, it is advisable to consult a healthcare professional before starting L-Tyrosine supplementation, especially if you have any pre-existing medical conditions or are taking other medications. In the following sections, we will explore the potential benefits and cautions associated with L-Tyrosine supplementation in more detail.

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Dr. Andrew Huberman recommends augmenting dopamine pathways to increase focus¹.


• Increased dopamine production: L-Tyrosine is a precursor to dopamine, a neurotransmitter associated with mood, motivation, and pleasure. Taking L-Tyrosine can help increase dopamine levels in the brain, leading to improved mood and motivation. • Enhanced cognitive function: L-Tyrosine has been shown to improve cognitive performance, especially in stressful or demanding situations. It can enhance focus, attention, and working memory, making it beneficial for tasks that require mental alertness and concentration. • Reduced stress and fatigue: L-Tyrosine can help alleviate stress and fatigue by supporting the production of stress hormones like adrenaline and noradrenaline. It can improve resilience to stress and promote a sense of calmness and mental clarity. • Improved exercise performance: L-Tyrosine has been found to enhance exercise performance by reducing the perception of fatigue and improving endurance. It can also increase the release of growth hormone, which aids in muscle recovery and growth. • Appetite regulation: L-Tyrosine plays a role in regulating appetite and satiety, potentially helping with weight management and controlling food cravings. It can support a healthy metabolism and prevent overeating. • Mental resilience and motivation: L-Tyrosine can enhance mental resilience and motivation, making it useful for individuals facing challenging situations or working on long-term goals. It can help maintain mental drive and determination. • Support for individuals with certain health conditions: L-Tyrosine supplementation may be beneficial for individuals with conditions such as depression, attention deficit hyperactivity disorder (ADHD), and Parkinson’s disease. It can potentially alleviate symptoms and improve overall well-being.


• Consult with a healthcare professional before starting L-Tyrosine supplementation, especially if you have any pre-existing medical conditions or are taking any medications. • L-Tyrosine may interact with certain medications, such as those used for thyroid disorders, high blood pressure, or antidepressants. It is important to discuss potential interactions with your doctor. • Individuals with overactive thyroid (hyperthyroidism), melanoma, or those on MAO inhibitors should avoid L-Tyrosine supplementation. • L-Tyrosine may increase blood pressure in some individuals, so it should be used with caution by those with hypertension. • Pregnant or breastfeeding women should avoid L-Tyrosine supplementation due to the lack of safety data. • L-Tyrosine may cause side effects such as headache, nausea, heartburn, or fatigue. If any adverse reactions occur, discontinue use and consult a healthcare professional. • It is important to follow the recommended dosage guidelines for L-Tyrosine and not exceed the recommended daily intake. • L-Tyrosine may interact with other supplements or herbs, such as thyroid support supplements or St. John’s Wort. Discuss potential interactions with your healthcare provider before combining these substances. • L-Tyrosine may affect levels of certain neurotransmitters, so it is important to monitor your mood and mental health while taking it. • While L-Tyrosine is generally well-tolerated, individual responses may vary. It is always best to start with a lower dosage and gradually increase if needed.


1. Rational Supplementation for Health & Performance

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